AFL.com.au has reporters stationed at venues across the country keeping a close eye on the action.
Melbourne has travelled north to face Gold Coast at Southport, with the match starting at 11:30am, Queensland time.
Port Adelaide has an opportunity to check its improvement when it hosts 2012 premiers the Sydney Swans at AAMI Stadium.
North Melbourne and Hawthorn will clash in Melbourne's outer-north suburb of Craigieburn, Richmond and the Western Bulldogs enter enemy territory at Visy Park while St Kilda travels to NSW to play the Giants at Blacktown.
Adelaide, Essendon, West Coast and Fremantle have the weekend off due to their earlier round one commitments.
On Friday night, the Brisbane Lions were crowned NAB Cup champions for 2013 after they accounted for Carlton at Etihad Stadium.
Meanwhile, Geelong easily accounted for Collingwood at Simonds Stadium on Friday, while injury-prone Bomber Scott Gumbleton snagged five goals in a VFL practice match.
Saturday March 16
Gold Coast v Melbourne at Southport, 11.30am
Port Adelaide v Sydney Swans at AAMI Stadium, 1pm
North Melbourne v Hawthorn at Craigieburn, 2pm
Richmond v Western Bulldogs at Visy Park, 2pm
GWS v St Kilda at Blacktown International Sportspark, 2pm
