The Saints were smashed last weekend by a rampant North Melbourne, who led by 55 points at the first change.
Their opponents at Etihad Stadium on Sunday afternoon, the Eagles, were similarly lacklustre, falling to Richmond by 41 points in Perth on Monday night.
"I know they'll be fired up," said Watters on Wednesday.
"They wouldn't be happy with that performance at home but we'll worry about what we need to deliver.
"We need to be ferocious from the start so we look forward to that."
A positive that Watters took out of the first-quarter thumping was that it was a learning experience for the younger, inexperienced members of his side who hadn't faced such early adversity before.
He said much of the match review had focused on that quarter, where his midfield were completely outclassed.
"It wasn't acceptable what we delivered, but we get a chance to learn from that and improve so that's where our focus is," Watters said.
"It's a steep learning curve for a lot of our younger players to go through that first quarter.
"It's about how young players respond early in the game to being put on the back foot by a side that was really up and about.
"They need to find solutions to get back in the game as quickly as possible.
"After quarter-time, once they had a chance to resettle, they played some better football."
Watters expected promising young Saint Nathan Wright to play on Sunday after copping a knock to his back against the Kangaroos.
Wright, 18, only recently returned from a broken jaw.
"He'll be tested later in the week but we think he'll be right to play.
"He's an unbelievably tough kid.
"We brought him straight back into the side off a broken jaw.
"It says a lot about an 18-year-old that based on his performances this year he comes straight back in."
