COLLINGWOOD'S horror run with injury has continued with key defender Darcy Moore suffering another hamstring issue against Sydney.

Moore, who was playing on Lance Franklin, left the field during the second quarter on Saturday night after straining his hamstring.

Franklin had kicked three first-quarter goals to that point and finished the game with 6.4 to be the difference in the Swans' two-point win over the Magpies. 

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Moore has already missed a total of 12 games with two separate hamstring injuries this season and while the severity of his latest problem is unknown, Buckley said the big defender's absence was costly.

"It's always nice to have the 22 you go in with. The guy that Darcy was playing on [Lance Franklin] ended up having 10 of their 18 shots on goal… so I think that was relatively significant, even though he had some in the first period as well," Buckley said.

"We were able to cover it for the majority of the game beyond Darcy leaving the field but once again, that third quarter sort of stands out as something that we didn't get right."