WESTERN Bulldogs skipper Katie Brennan is in danger of missing the rest of the NAB AFLW season in a major blow to her team's premiership aspirations.

Brennan sustained minor ligament damage to her right ankle in the final two minutes of the Bulldogs' seven-point loss to reigning premiers Adelaide at Norwood Oval on Saturday.

The Bulldogs haven't provided a time-frame for Brennan's return.

It's the same ankle that restricted Brennan to only two games last season, although that was a tendon injury.

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Bulldogs AFLW coach Paul Groves remains optimistic Brennan can play a part on the field.

"We know Katie will do everything possible to ensure she can get back out there before the end of the season," Groves said in a club statement.

"While it's unclear how many weeks she might miss, she has already started working with our medical staff to make sure she recovers at the earliest opportunity.

"As one of our leaders, Katie will be difficult to replace, but the group of players who have missed selection are working extremely hard to be ready for their opportunity.

"We have great confidence in those players to make an impact at this level, which shows the level of depth in our current playing group."

Brennan, 25, has booted five goals in three games this year and is one of the leading forwards in the competition.

The Bulldogs are one of five sides with a 2-1 win-loss record on the congested ladder with four rounds to go before the Grand Final.

The Bulldogs host Carlton at Whitten Oval on Friday night.