GREATER Western Sydney has suffered another significant injury blow on the eve of its clash with rivals the Western Bulldogs, with star midfielder Josh Kelly a late withdrawal due to calf tightness.

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Kelly joins fellow gun Toby Greene on the sidelines, with young midfielder Jackson Hateley returning to the team for his first game of the season.

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"With a five-day break between games, we aren’t taken any risks with Josh," Giants footy boss Jason McCartney said.

"At this stage we’re confident he’ll be able for selection next week.

"Jackson Hately has been banging the door down with his training form and we’re confident he’ll be able to play a role tonight."

Greene (knee) and young defender Isaac Cumming (omitted) had already been left out of the side to take on the Bulldogs earlier in the week, replaced by debutant Lachie Ash and small forward Zac Langdon.

The Bulldogs will line up as selected, with premiership trio Zaine Cordy, Toby McLean and Toby Liberatore all returning.