PORT Adelaide star Zak Butters might have played his last game for the club after suffering an ankle injury against St Kilda on Saturday afternoon.

Butters landed awkwardly after an attempted spoil on a Max Hall mark late in the third term, with his right ankle getting caught and twisted in the legs of Hall.

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The 25-year-old immediately grabbed at it and looked in serious pain as he was walked off the field at Marvel Stadium in the hands of trainers.

"It's not looking good. The vision speaks for itself, so we'll have to wait and see," Port coach Josh Carr said post-game.

"We had a bit going on through the game.

"Zak had a great third quarter and you see the way that he plays - he never gives up.

"He probably didn't need to get himself in that situation, but that's just who he is."

There was injury chaos for the Power, who had one fit player on the bench by the end of the game after also losing Lachie Jones (ribs) and Mitch Georgiades (concussion) to injury earlier in the match.

The restricted free agent has consistently said he won't make his decision on his future until he falls off-contract with Port at the end of the season, but the Western Bulldogs, who Victorian-born Butters supported as a kid, are considered frontrunners for his services.

Geelong, Hawthorn, Collingwood, Melbourne, Essendon and Richmond have also expressed interest in the gun midfielder, who has won Port's club champion award for the past three seasons and is odds-on to collect a fourth this year.

With only six rounds remaining in the season and the Power unlikely to feature in September, even a mid-range absence for Butters would end his season and - if he joins a new club in the off-season - signal his final act as a Port Adelaide player.