RICHMOND star Brett Deledio is out of the Tigers' round-one match with Carlton on Thursday night after injuring his quadriceps.
Deledio, 28, ran laps at training on Sunday but left the track early.
The vice-captain only played one game in the pre-season after struggling with calf issues.
He pulled up sore after playing just over a half of the Tigers' NAB Challenge clash against Port Adelaide 11 days ago and football manager Dan Richardson said he was yet to make a full recovery.
"'Lids' is unlikely to play this week; he's had some tightness in his quad, hence you saw yesterday he was on a restricted program," Richardson said.
"At this stage we don't think he'll be any better tomorrow so we won't take the risk.
"It's not too bad, it's nothing serious, but we think it's probably better not to take the risk."
The injury comes as yet another blow for Richmond. Recruit Chris Yarran requires foot surgery and will miss for six weeks while Reece Conca won't play for at least eight weeks with a hamstring injury.
Deledio pushed hard to play in last year's season opener against Carlton but paid the price, missing the next four games with an injured calf.
Richardson said he expected Deledio to be available for the Tigers' round-two clash against Collingwood on April 2.
Meanwhile, half-forward Shane Edwards has recovered from shoulder bruising and is set to face Carlton on Thursday night after completing Sunday's training session.
Midfielder Shaun Grigg is unlikely to face the Blues as he recovers from thumb surgery, Richardson said.