The Bombers followed an equally gutsy win over Carlton with a disappointing loss to the Kangaroos, but Knights does not fear a similar outcome at the Gabba.
"I don't think it's about getting carried away; it's just that every week you are rising to the challenge against a good team," he said.
"People have to understand you are going up against another AFL team with 22 talented players – they are going to want to win as much as you are on any given day."
The Lions suffered a huge loss at the hands of Geelong last week at Skilled Stadium, but Knights hasn't read too much into that match in assessing his opponent's form.
"They're a pretty formidable force up at the Gabba on their home ground," he said.
"They've got two great forwards [Jonathan Brown and Daniel Bradshaw] who are difficult to counteract on any given week. It's a huge challenge for our young defenders, but we go up there with decent form and we're really excited about the prospect of having a crack at them.
"We've just got to continue to try and play our game and be aggressive. I've just got to continue to back our youth in and hopefully over time our consistency becomes a little bit better, because that's been a challenge up to this point."
Cale Hooker has been drafted in to assist Paddy Ryder in the ruck this week ahead of specialist ruckmen Tom Bellchambers and Christian Bock, with Knights backing the versatility that Hooker brings at 196 cm.
Important onballer Mark McVeigh wasn't considered after experiencing soreness in the ankle that has restricted him to just one match this season, but Knights is hopeful he will be ready to go next week.
Skipper Matthew Lloyd and midfielder Sam Lonergan, both of whom suffered cork injuries in the Anzac clash, will be monitored, but are expected to be ready to play against the Lions.
The match will be Dustin Fletcher's 300th in the top flight and Knights said it was a milestone worthy of the highest praise.
"It is an enormous effort in football to play 300 games so we'll certainly be making a big deal of it," he said.
"We've spoken about it yesterday in a team meeting and obviously before the game we'll touch on his importance to the group and, more importantly, his importance to the club over a long period."
As of Friday morning, Knights had not yet spoken to David Hille, who underwent a knee reconstruction on Thursday afternoon, but said he would soon speak to the ruckman about a mentoring role during his rehabilitation.
"I think David can really play a role with those two young ruckmen [Bellchambers and Bock] and actually hopefully Jason Laycock [as well] because they're both going to be in rehab for a short period together," he said.
"[But] don't get it wrong he's going to be a massive loss for us. You don't lose experienced players like that with big bodies who have been your best and fairest and it not have an impact."
