Fremantle has suffered an unprecedented run with injuries this season and in round 10 the side played much of its second half against Richmond with 17 fit men.
Pavlich, who sits on the AFL Laws of the Game Committee, said he would support a system where a player injured early in the match could be permanently replaced by a substitute.
“I think if there's a genuine injury up to quarter time, half time – I'm not really sure where the line should be drawn – the travelling emergency could come on and play, I think it's a great idea," Pavlich said from Fremantle Oval on Tuesday.
"Whether or not it becomes implemented we'll wait and see - I'm sure all the powerbrokers will discuss that when the time comes."
Fremantle lost Luke McPharlin, Des Headland and Stephen Hill early in its loss to Richmond, while Antoni Grover and Paul Hasleby were forced to play through injury.
It also lost tall forward Adam Campbell early in the weekend's loss to Port Adelaide.
North Melbourne was forced to play out its round 11 loss to St Kilda one man short on the field and Pavlich said the recent examples illustrated the importance of rotations in modern football.
"Against Richmond we had six rotations in the last quarter to their 22," Pavlich said.
"I'm not saying it played a huge part, because we had a good last quarter – I think we outscored them – but it certainly plays a part.
"This day and age with football the way it's played and the intensity and the energy levels that are needed, having those rotations or conversely having a lack of rotations certainly disadvantages one side."
The substitution rule trialled in the NAB Cup won plenty of fans with Pavlich and Harvey joined by Mick Malthouse and Michael Voss in the call for change.
Pavlich said, like any rule, coaches would try to exploit a substitute system for their own gain, and the rule should only be applied up to a certain point in matches.
"There has to be a cut off at some point," he said.
"We could substitute a guy in the last quarter, well that's obviously not going to happen – there needs to be sense about these things.
"[It would need to be] a legitimate injury, which would probably have to be checked out by an independent doctor either at that time or certainly after the game.
"There has to be some pretty stringent scenarios."
Fremantle doesn't play this weekend and Pavlich said the week off would provide the players with a much-needed chance to freshen up physically and mentally.
He said it would be a light week on the training track and the players would spend the weekend away from the club before preparing for Geelong in the second week of the split round.
