REIGNING premiers Adelaide have suffered a double injury blow ahead of Saturday's season-opener against Brisbane, with experienced defender Courtney Cramey and midfielder Sophie Li not making the trip.

Cramey – a dual-premiership winner and part of the club's leadership group – has been ruled out of the clash with the Lions at Hickey Park with groin soreness, while Li is still feeling the effects of a concussion sustained in a practice game against Fremantle two weeks ago.

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Taking their place are 19-year-old midfielder Jaimi Tabb and 20-year-old ruck Caitlin Gould, who will both be making their debuts.

They join Najwa Allen, Chelsea Biddell, Nicole Campbell, Madison Newman and Courtney Gum – the former GWS star who has come out of retirement – as seven newcomers in the Crows' depleted line-up.

The Crows only have 21 of their initial 30-player list available for selection, with train-on players Rachelle Martin and Czenya Cavouras travelling with the team as emergencies.

Young ruck Montana McKinnon wasn't considered after she suffered knee soreness that required a scan on Thursday night.

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Superstar Erin Phillips, ruck Rhiannon Metcalfe and forward Chloe Scheer are recovering from knee reconstructions, wing Deni Varnhagen (knee) is expected to play in the second half of the season and inspirational co-captain Chelsea Randall will miss the season with a torn ACL.