Andrew McInnes and Tom Temay leave the club, along with rookies Jaryd Cachia and Luke Reynolds.
Josh Bootsma's contract was terminated in July while Heath Scotland and Nick Duigan have already retired.
The Blues' football operations manager, Andrew McKay, thanked the players for their time at Carlton.
“Each of these players has made a contribution to our football club,” McKay said.
“We would like to thank them for all their hard work over the journey and wish them all the very best for the future.”
McInnes played just the single game for Carlton in 2014 for a career total of 17.
Temay was not able to register a senior appearance at the club during two years on the list, despite being picked at No.35 in the 2012 NAB AFL Draft.
Reynolds couldn't manage a senior call-up after being picked at No.43 in last year's rookie draft.
Cachia likewise didn't play a game in 2014 and his Carlton career finishes at 14 games in total.