MELBOURNE has lost a second defender ahead of its Darwin clash with Adelaide, with Christian Salem a late scratch following Marty Hore's earlier withdrawal.

Salem was set to return from concussion but illness has postponed his comeback for another week, while first-year Demon Hore misses with calf soreness. 

Key forward Sam Weideman joins Jay Kennedy Harris as a late inclusion for Melbourne, making it four changes from last week, on top of Michael Hibberd and Mitch Hannan coming in. 

FOLLOW IT LIVE Demons v Crows

The Crows also made a late change for team balance reasons, replacing key backman Kyle Hartigan with 211-game veteran David Mackay, who had a virus a week earlier.

Tom Lynch, Josh Jenkins and Bryce Gibbs are Adelaide's other additions to last week's squad.

Saturday night's match is at Darwin's TIO Stadium, where the Crows beat Melbourne by 46 points in 2017, but the Demons returned the favour in Alice Springs last year in a 91-point result.

Melbourne v Adelaide at TIO Stadium, 7.10pm ACST

LATE CHANGES
Melbourne:
Christian Salem (illness) replaced in selected side by Sam Weideman, Marty Hore (calf soreness) replaced in selected side by Jay Kennedy Harris
Adelaide:
Kyle Hartigan (team balance) replaced in selected side by David Mackay

FINAL INTERCHANGES
Melbourne: Charlie Spargo, Angus Brayshaw, Bayley Fritsch, Oskar Baker
Adelaide: Hugh Greenwood, Bryce Gibbs, Jordan Gallucci, David Mackay

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Brisbane v Hawthorn at the Gabba, 7.25pm AEST

NO LATE CHANGES

FINAL INTERCHANGES
Brisbane: Lewis Taylor, Alex Witherden, Rhys Mathieson, Archie Smith
Hawthorn: Mitch Lewis, Conor Glass, Isaac Smith, James Cousins

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Geelong v Sydney at GMHBA Stadium, 4.35pm AEST

LATE CHANGES
Geelong: Rhys Stanley (adductor) replaced in selected side by Zac Smith
Sydney: Nil

FINAL INTERCHANGES
Geelong: Brandan Parfitt, Gryan Miers, James Parsons, Jack Henry
Sydney: Daniel Menzel, Nick Blakey, Jacob Dawson, Robbie Fox

Collingwood v Fremantle at the MCG, 1.45pm AEST

NO LATE CHANGES

FINAL INTERCHANGES
Collingwood: James Aish, Callum Brown, Travis Varcoe, Tom Phillips
Fremantle: Adam Cerra, Reece Conca, Ethan Hughes, Brett Bewley

Greater Western Sydney v Gold Coast at Giants Stadium, 1.45pm AEST

NO LATE CHANGES

FINAL INTERCHANGES
Greater Western Sydney: Jacob Hopper, Brent Daniels, Adam Tomlinson, Adam Kennedy
Gold Coast: Anthony Miles, Jordan Murdoch, George Horlin-Smith, Josh Schoenfeld