MELBOURNE has made two late changes ahead of Thursday night's must-win clash with Sydney, losing star defender Neville Jetta and small forward Jay Lockhart.

Jetta will miss with a knee injury and has been replaced in the side by Marty Hore, while Lockhart – who has been replaced by Charlie Spargo – is suffering back soreness.

FOLLOW IT LIVE Swans v Demons

Hore and Spargo both last played in round one, with Spargo spending a fortnight on the sidelines with a jaw injury.

The Swans are unchanged, meaning former co-captain Kieren Jack will play his first game for the season, returning from knee soreness, while Justin McInerney will make his debut.

McInerney, a winger, was drafted from the Northern Knights with pick 44 last year.

The Demons have never defeated Swans superstar Lance Franklin, who is out to make his record 16-0 against Melbourne.

Sydney v Melbourne at the SCG, 7.20pm AEST

LATE CHANGES
Sydney: Nil
Melbourne: Neville Jetta (knee) and Jay Lockhart (back) replaced in selected side by Marty Hore and Charlie Spargo

FINAL INTERCHANGES
Sydney: Jackson Thurlow, Kieren Jack, Nick Blakey, Justin McInerney
Melbourne: James Harmes, Sam Wiedeman, Corey Wagner, Josh Wagner