ST KILDA superstar Nasiah Wanganeen-Milera has suffered a potential season-ending left hamstring injury against Carlton in a deflating blow to the Saints' wildcard hopes.

Veteran Mason Wood was also ruled out with a calf injury late in the second quarter, which could finish his season too.

In the first quarter of Sunday night's high-stakes clash at Marvel Stadium, Wanganeen-Milera handballed to teammate Max Hall, attempted to burst away then grabbed at his hamstring as he tried to receive the ball back.

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A dejected Wanganeen-Milera limped straight down to St Kilda's rooms and there will clearly be concerns over the severity of the injury.

The 23-year-old emerged a few minutes later but shuffled to the bench and took a seat in the back row, banging the glass behind him in frustration, before later having it iced.

The Saints later confirmed Wanganeen-Milera would, as expected, take no further part in the game, which was pivotal in the bid for a wildcard spot.

Ahead of the game, 10th-placed Carlton (40 points) were just one win clear of 11th-placed St Kilda (36).

Even a standard hamstring would realistically rule Wanganeen-Milera out of remaining games against Richmond and Gold Coast, seriously denting the Saints' hopes of claiming a wildcard berth.

Wanganeen-Milera had been under an injury cloud all week, missing Thursday's training as he battled a hip pointer issue suffered in last week's loss to Sydney - but was ultimately cleared to play.

The 23-year-old has averaged 30 disposals, a goal and a direct goal assist this season, but has been red-hot in recent weeks.

Two weeks ago, Wanganeen-Milera kicked four goals and had 46 disposals - one of three hauls of 40-plus disposals in the past six weeks - while he still collected three goals and 24 touches against the Swans last week.