ST KILDA has confirmed Dan Hannebery and Jake Carlisle will make their long-awaited return to AFL football in Saturday's clash against Brisbane.

Hannebery, who joined the Saints from Sydney last year, will make his St Kilda debut after two solid outings in the VFL.

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The three-time All Australian's season has been hampered by persistent hamstring and calf issues.

Carlisle will also play his first senior game of the season after undergoing back surgery on the eve of round one.

The 27-year-old only featured once at VFL level, but showed enough to earn senior selection this week.

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