THE STAKES are sky high and finals could be on the line when St Kilda takes on West Coast from 7.10pm AEST.

With a clash against Greater Western Sydney to come, St Kilda is in massive danger of falling out of the top eight completely after spending most of the year on the upper rungs of the ladder.

The Saints are a game behind fifth-placed West Coast but are a chance of moving ahead if they gain a small amount of percentage.

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Meanwhile, West Coast is eyeing a top-four spot and is just a game behind third-placed Geelong and half a game in arrears of Richmond.

01:38 Mins
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Match Previews R17: St Kilda v West Coast

Sportsbet's Nathan Brown and Michael Wall preview the game between the Saints and the Eagles at the Gabba

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The Eagles have made a whopping six changes for the clash, with former skipper Shannon Hurn and ruckman Nic Naitanui among those returning.

LADDER PREDICTOR Can your team make the eight?

But they have been smashed by injury following their two-point loss to the Western Bulldogs on Sunday, losing Dom Sheed, Jack Redden, Lewis Jetta, Mark Hutchings and Brandon Ah Chee.

FULL TEAMS Check 'em out

Ruckman Tom Hickey has been omitted to make way for Naitanui, who was rested for the Dogs clash.

Hurn, Will Schofield, Jarrod Brander, speedster Jack Petruccelle and debutant Hamish Brayshaw will all play for the Eagles, while St Kilda has bolstered its forward line, recalling Max King (after he was managed), spearhead Tim Membrey, and the zippy Nick Hind.

Ryan Abbott, Ed Phillips and Jonathon Marsh have all been left out.