MELBOURNE has extended its undefeated start to the season with a 34-point win over Greater Western Sydney at Manuka Oval, where the hosts' woes were compounded by injuries to Stephen Coniglio, Phil Davis and Matt de Boer.

The effort, intensity and competitiveness of the Giants could not be questioned, especially compared to their preceding woeful loss to Fremantle in Perth.

But Leon Cameron's side, already under pressure and sorely missing injured stars Lachie Whitfield and Jesse Hogan, risks hitting crisis point soon if it fails to upset Collingwood in a must-win MCG match on Saturday night.

07:54 Mins
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Highlights: GWS v Melbourne

The Giants and Demons clash in round three

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The Giants, desperate to make a statement after their first 0-2 start to a season since 2013, started strongly then dug deep after captain Coniglio and key defender Davis limped off in the second quarter and played no further part in the match.

De Boer, who curbed the influence of Clayton Oliver throughout the opening half, tweaked his hamstring in the third quarter to ensure yet another member of the expansion club's leadership group failed to finish the game.

The Demons, who conceded three of the game's opening four goals, seized control and withstood a spirited final-quarter challenge to triumph 15.12 (102) to 11.2 (68).

00:32 Mins
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Demons open their account with this delightful goal from the pocket

Alex Neal-Bullen perfectly roves and dribbles from the boundary

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The result means Melbourne joins the Western Bulldogs and Sydney as the only teams yet to lose after three rounds, while the under-siege Giants and last-placed North Melbourne are the only sides yet to sing their song.

It is the Demons' first 3-0 start to a season since 2005.

GIANTS v DEMONS Full match coverage and stats

Toby Greene's fourth and fifth goals, coming in the first two minutes of the final term, reduced the visitors' buffer to a six points, however, Melbourne settled with five consecutive goals, including two from speedster Kysaiah Pickett.

Pickett kicked four goals for the match to continue his eye-catching start to the year, including a remarkable third-quarter effort in which he created a turnover out of nothing then plucked the ball off the ground and snapped truly.

02:46 Mins
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Pickett weaves his magic in stunning display

Young Demon Kysaiah Pickett showed his class with a career-high four-goal effort against the Giants

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Captain Max Gawn booted two goals, bossed the stoppages and clutched five contested marks to headline the visitors' list of best-on-ground contenders, which also included Pickett, Jack Viney, Christian Petracca, Angus Brayshaw, Ed Langdon and Jayden Hunt.

GWS was forced to activate its medical substitute, thrusting Nick Shipley into the fray, after Davis suffered an innocuous lower-leg injury at the start of the second quarter.

Coniglio, who stood up alongside Tim Taranto and Josh Kelly after the Giants' midfield copped a week of heavy criticism, was in obvious discomfort after being tackled by Tom Sparrow.

Young Giant Brent Daniels also hurt his ankle late in the opening half, but was able to return to the park.

00:29 Mins
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Giants star makes the most of slick assist

The Giants score their second major through Jacob Hopper after a brilliant goal assist from Josh Kelly

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Giants in a world of pain
A 0-3 start to the season is bad enough, but with the injury toll mounting at the Giants, Leon Cameron must already be keeping his management high on the speed dial. The ankle injuries to Phil Davis and Stephen Coniglio weren't the type that carry a viewer warning, but the more innocuous an injury is, the more major it can be. And Matt de Boer's hamstring is almost certainly a few weeks out just when he was back to his constricting best. Add this trio to Lachie Whitfield, Jessie Hogan, Adam Kennedy and Braydon Preuss, and there are holes all over the ground. At the moment Cameron may just be hoping one of them is big enough to hide in.

00:27 Mins
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Leg injury ends Coniglio's night early

GWS skipper Stephen Coniglio limps from the field after injuring his lower leg in a tackle

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The grass is always Greener
Like Dustin Martin, Toby Greene is the modern footballing conundrum: good guy or villain, forward or midfielder? Greene did his best to drag the Giants back into the game early in the final term after keeping them close for most of the night, but you can only do so much while waiting for the ball to arrive. Leon Cameron knows his best forward is running around in the No.4 guernsey, but maybe more goals would come if Toby was banging the ball down Harry Himmelberg's throat, and dragging the Giants' sometimes less-than-highly-motivated mids into the contest by their ears. It'll be interesting to see if Greene spends a little more time on the ball in the next few weeks, especially if Jessie Hogan can get on the ground.

00:41 Mins
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Greene gives his team a Giant lift with two in a minute

Toby Greene starts off the last term with two quick majors to get the Giants back in the contest

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Is the devil off the Demons' backs?
A preliminary final in 2018 set the bar high for Simon Goodwin's side, too high for it clear in the two seasons since, but maybe, just maybe, this is the year. Melbourne has teased and tortured its fans since Ronald Dale Barassi was in short pants and it's unlikely they are taking anything for granted just yet, but there seems to be a determination to work more and celebrate less in this group. Maybe it's the honest simplicity of Max Gawn's leadership, maybe it's a list that doesn't want to waste its talent. Whatever the motivation, it's given the club its best start to a season in 15 years, now let's see how far it rolls on.

GREATER WESTERN SYDNEY   5.1    7.1     8.1    11.2 (68)
MELBOURNE                             2.3    6.5   10.7   15.12 (102)

Greater Western Sydney: Greene 5, Kelly 2, Himmelberg, Hopper, O'Halloran, Green
Melbourne: Pickett 4, Fritsch 3, Gawn 2, Jackson, Neal-Bullen, Petracca, Spargo, Brayshaw, Jordan

Greater Western Sydney: Taranto, Greene, Kelly, Ash, Haynes, Hopper
Melbourne: Gawn, Viney, Hunt, Brayshaw, Pickett, Langdon

Greater Western Sydney: Davis (ankle), Coniglio (ankle), de Boer (hamstring)
Melbourne: TBC

Greater Western Sydney: Shipley (replaced Davis)
Melbourne: Melksham (unused)

Crowd: TBC at Manuka Oval