CLASSY Greater Western Sydney midfielder Josh Kelly has been ruled out of his team's Tuesday night clash with Adelaide, which will be the second consecutive game he has missed.

Kelly was concussed in the Giants' round 14 match against Fremantle and coach Leon Cameron told reporters on Monday his star onballer had been a bit "patchy".

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Cameron said he was hopeful Kelly would be available for the crucial clash with Melbourne on Saturday.

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In more bad news for the Giants, important trio Brent Daniels, Harry Perryman and Zac Williams are also unlikely to take the field against the Crows, while ruckman Shane Mumford will definitely sit out after playing three consecutive games.

"Harry's calf doesn't look like it will come up, Brent is tight in his hamstring and Zac with his Achilles just hasn't responded after the two short breaks," Cameron said.

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"Shane, we'll manage. He's played three games in a row. But we're disappointed with the other three, because clearly they're in our best 22. 

"Josh's week has been a bit patchy. Clearly, the hit in the Fremantle game has knocked him around a fair bit.

"We were expecting him to get up for this game and we're disappointed that he's not. But we're hopeful that he's ready for the next game on Saturday.

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"It's been a bit patchy, but he's started to come out the other side over probably the last 24 hours. But it just becomes too late on the concussion protocol.

"Hopefully he can be back on Saturday, but in saying that we'll be determined by what the doctors say. If he's right, then he gets picked. If he's not, then he has to sit out again."

The Giants will face off against their former assistant coach Matthew Nicks, who took the Crows' senior coaching reins from Don Pyke.

Cameron said the club was upset to lose Nicks after the 2019 season, but knew he was ready for a senior coaching role.

"We were clearly disappointed to lose him ... he's a terrific person and a terrific coach," Cameron said.

"But he was always destined to become a senior coach and that's what he's fulfilling at the moment.

"But on the weekend, we're arch enemies. We know the situation we're in, we just need to keep winning. We can't afford to drop any games."