West Coast, awarded home advantage based on its heavy travel load during the season, could complete its entire pre-season at Patersons Stadium if it can knock off the reigning premiers.
The first semi-final between Essendon and St Kilda will be the second meeting between the sides this year, after their drawn game in the first round of the NAB Cup.
The AFL also confirmed the next round of NAB Challenge fixtures, with Gold Coast and the Sydney Swans doing battle at Southport, while Fremantle and the Western Bulldogs will travel to Bunbury.
NAB Cup
Friday March 4
Essendon v St Kilda at Etihad Stadium, 7.40pm
Saturday March 5
West Coast v Collingwood at Patersons Stadium, 5.40pm
NAB Challenge
Friday 4 March
Richmond v Hawthorn at Shepparton, 7pm
Port Adelaide v Geelong Cats at AAMI Stadium, 7pm
Carlton v Adelaide at Visy Park, 4pm
Saturday 5 March
GWS Giants v North Melbourne at Lavington, 7pm
Fremantle v Western Bulldogs at Bunbury, 3.30pm
Gold Coast Suns v Sydney Swans at Southport, 3pm
Melbourne v Brisbane Lions at Visy Park, 1pm
