Brown has been eased back into the side following a cautious pre-season and will gain some valuable match practice at Cazaly Stadium against the Demons.
It will be Brown’s first official hit-out since he was appointed sole Club Captain back in October last year.
The Lions have also welcomed back Vice-Captain Luke Power, Travis Johnstone, Jared Brennan and Michael Rischitelli to the side.
Tim Notting, Ashley McGrath, Justin Sherman and Daniel Dzufer have been rested from the side that lost to Essendon by two points in Melbourne last week.
The Lions will field their strongest of the pre-season with Vice-Captains Simon Black, Daniel Merrett and ruckman Jamie Charman the most notable absentees.
Brisbane Lions unplaced squad of 29 players:
1. Mitch Clark
2. Albert Proud
4. Travis Johnstone
5. Scott Harding
6. Luke Power
7. Jed Adcock
10. Daniel Rich
12. James Hawksley
14. Lachlan Henderson
15. Matt Tyler
16. Jonathan Brown
17. Jared Brennan
22. Tom Collier
23. Matthew Leuenberger
24. Joel Patfull
26. Joel Macdonald
28. Troy Selwood
29. Jason Roe
30. Jack Redden
31. James Polkinghorne
32. Cheynee Stiller
33. Rhan Hooper
34. Bradd Dalziell
35. Michael Rischitelli
36. Daniel Bradshaw
37. Matt Austin
39. Josh Drummond
41. Scott Clouston (NB: pronounced Clue-ston)
44. Aaron Cornelius
