RICHMOND captain Trent Cotchin will be sidelined for up to three weeks with a left hamstring strain, while teammate Jayden Short is expected to be out for at least two months.
Short dislocated his right elbow in the opening minutes of the 49-point loss to Greater Western Sydney and has damaged ligaments in his arm.
He requires a consultation with a surgeon, with a clearer timeframe to be decided after that.
"We're obviously disappointed to lose Trent and Jayden to injury for a period of time, both players will go through their rehab and recovery processes, and we look forward to getting them both back in due course," Richmond general manager of football Neil Balme said.
"Fortunately, we expect to bolster the team with some players to return from injuries, as we as Dylan Grimes (suspension) available for selection."
Forward Josh Caddy played 70 per cent game time in the VFL on Friday night in his return from an ankle injury, while running back Bachar Houli has been listed as "probable" by the club after missing two weeks with a hamstring strain.
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Small forwards Mav Weller (leg) and Jake Aarts (corked calf) both missed the VFL match and are touch and go to play this weekend.
Three-time Coleman medallist Jack Riewoldt is at least two weeks away (wrist), while experienced mid Shaun Grigg (knee) is still quite some way off.
Five-time All Australian key back Alex Rance is out for the year with a torn ACL.