COLLINGWOOD and Essendon have combined for eight changes for Sunday's Anzac Day blockbuster at the MCG.
The Pies will unveil debutant Jay Rantall, while youngsters Nathan Murphy and Will Kelly will play their first games of the season alongside fellow inclusions Will Hoskin-Elliott and Trey Ruscoe.
Jeremy Howe, Chris Mayne, Jordan De Goey and Levi Greenwood will miss with injuries and Mark Keane through suspension, with emergencies Brayden Sier and Tyler Brown contenders for the substitute role after sitting out the VFL loss to Essendon on Saturday.
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For the Bombers, Brandon Zerk-Thatcher returns for extra height in defence given Zac Reid (illness) and Jordan Ridley (concussion) have been sidelined.
Andrew Phillips is also back to tackle Brodie Grundy, last week's medical substitute Matt Guelfi has been named in the starting side and Alec Waterman has been dropped.
David Zaharakis looms as the Bombers' sub given he was the only emergency not to play in the VFL
St Kilda coach Brett Ratten has reacted to last week's drubbing at the hands of Richmond with Jack Bytel, Paul Hunter and Luke Dunstan dumped to join Jimmy Webster (groin) on the sidelines for their clash with Port Adelaide.
Zak Jones and Rowan Marshall are back alongside last week's sub Ben Long and Irish defender Darragh Joyce, who will play his first game since round 11, 2019. The Saints sat three emergencies – Mason Wood, Jack Bytel and Tom Highmore – out of Sandringham's VFL clash on Saturday.
The Power will debut Martin Frederick in place of Lachie Jones, with Sam Mayes dumped in place of last week's medical sub Willem Drew.
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Adelaide has made a shock call for its meeting with Hawthorn, dumping veteran Tom Lynch and Billy Frampton, while last week's sub Nick Murray has been left out of the squad altogether.
No.2 draft pick Riley Thilthorpe will debut, Jack Hately will play his first game for the Crows and Elliott Himmelberg has been recalled from the SANFL.
Lynch, however, appears the likely sub as the Crows' only emergency not playing in their SANFL side on Saturday.
At the Hawks, Mitch Lewis is back from suspension and round five medical sub James Cousins has been named in the starting 22, with Conor Nash and Daniel Howe omitted.
The Hawks kept emergencies Connor Downie, Michael Hartley and Finn Maginness out of Box Hill's VFL encounter on Saturday.
Sunday, April 25
Hawthorn v Adelaide at University of Tasmania Stadium, 12.30pm AEST
Out: D.Howe (omitted), C.Nash (omitted)
Last week's sub: J.Cousins (unused)
In: E.Himmelberg, R.Thilthorpe, J.Hately
Out: B.Frampton (omitted), T.Lynch (omitted), S.Berry (ankle), N.Murray (omitted)
Last week's sub: N.Murray (unused)
Collingwood v Essendon at the MCG, 3.20pm AEST
In: W.Kelly, N.Murphy, W.Hoskin-Elliott, T.Ruscoe, J.Rantall
Out: B.Sier (omitted), M.Keane (suspension), J.Howe (hamstring), C.Mayne (concussion), J.De Goey (concussion), L.Greenwood (concussion)
Last week's sub: B.Sier (replaced J.De Goey)
In: B.Zerk-Thatcher, A.Phillips
Out: Z.Reid (illness), J.Ridley (concussion), A.Waterman (omitted)
Last week's sub: M.Guelfi (replaced J.Ridley)
Port Adelaide v St Kilda at Adelaide Oval, 6.10pm ACST
Out: S.Mayes (omitted), L.Jones (ankle)
Last week's sub: W.Drew (replaced D.Houston)
In: R.Marshall, D.Joyce, Z.Jones
Out: J.Bytel (omitted), P.Hunter (omitted), L.Dunstan (omitted), J.Webster (groin)
Last week's sub: B.Long (replaced J.Webster)