How will Max Gawn and the Demons bounce back from a week of scrutiny after their shock loss to Port Adelaide in round one? Will the Cats target the Dees' big ruckman again?
Or will it be a repeat of the thrilling last-gasp finish when Geelong and Melbourne last met at GMHBA Stadium?
Follow all the live scores and stats, plus the action from the Eagles-Giants clash at Optus Stadium via the AFL.com.au match centre.
FOLLOW IT LIVE Cats v Demons
Geelong v Melbourne at GMHBA Stadium, 7.25pm AEDT
NO LATE CHANGES
FINAL INTERCHANGES
Geelong: Charlie Constable, Sam Menegola, Gryan Miers, Jack Henry
Melbourne: Angus Brayshaw, Michael Hibberd, Bayley Fritsch, Jay Lockhart
FOLLOW IT LIVE Eagles v Giants
West Coast v Greater Western Sydney at Optus Stadium, 5.10pm AWST
NO LATE CHANGES
FINAL INTERCHANGES
West Coast: Jack Redden, Tom Hickey, Daniel Venables, Tom Cole
Greater Western Sydney: Jacob Hopper, Brett Deledio, Adam Kennedy, Sam Reid
FOLLOW IT LIVE Power v Blues
Port Adelaide v Carlton at Adelaide Oval, 4.40pm ACDT
NO LATE CHANGES
FINAL INTERCHANGES
Port Adelaide: Sam Powell-Pepper, Paddy Ryder, Connor Rozee, Darcy Byrne-Jones
Carlton: Paddy Dow, Jarrod Garlett, Cam Polson, Alex Fasolo
FOLLOW IT LIVE Bombers v Saints
Essendon v St Kilda at Marvel Stadium, 4.35pm AEDT
NO LATE CHANGES
FINAL INTERCHANGES
Essendon: Darcy Parish, Kyle Langford, Dylan Shiel, Matt Guelfi
St Kilda: Jack Steven, Luke Dunstan, Blake Acres, Callum Wilkie