CARLTON overran rivals Melbourne by 16 points at Traeger Park in Alice Springs to steal a crucial march in the race for finals.
The Blues held the Demons to just three behinds after half-time, moving to second place on the Conference B table.
WATCH IT LIVE How to follow the AFLW this weekend
Collingwood also proved its premiership credentials thanks to a 29-point demolition of Brisbane at Hickey Park.
The day's other game saw St Kilda keep fellow newcomers Richmond goalless, cruising to a 39-point victory at RSEA Park on the back of Caitlin Greiser's three majors.
FULL FIXTURE Every round, every game
Supporters will not be permitted to attend NAB AFLW matches from Saturday, March 14, due to the everchanging nature of the COVID-19 pandemic.
Saturday, March 14
Brisbane v Collingwood, Hickey Park, 2.10pm AEST
BRISBANE 0.1 0.1 2.2 2.2 (14)
COLLINGWOOD 2.4 3.7 3.10 5.13 (43)
LIONS v MAGPIES Full match coverage and stats
St Kilda v Richmond, RSEA Park, 5.10pm AEDT
ST KILDA 2.1 2.1 4.5 6.6 (42)
RICHMOND 0.0 0.2 0.2 0.3 (3)
SAINTS v TIGERS Full match coverage and stats
Melbourne v Carlton, TIO Traeger Park, 6.10pm ACST
MELBOURNE 2.3 3.3 3.5 3.6 (24)
CARLTON 1.1 2.1 4.1 6.4 (40)
DEMONS v BLUES Full match coverage and stats
Friday, March 13
Geelong v North Melbourne, GMHBA Stadium, 7.10pm AEDT
GEELONG 2.1 3.2 3.2 3.2 (20)
NORTH MELBOURNE 0.2 2.3 6.4 10.6 (66)
CATS v ROOS Full match coverage and stats