Essendon and coach James Hird are challenging the legality of the Australian Sports Anti-Doping Authority's investigation.
The judgement will be delivered at 1.30pm AEST at the Federal Court in Melbourne and live television coverage will be provided.
If Justice Middleton rules in favour of ASADA, its chief executive BenMcDevitt will be free to pursue show-cause notices against 34 past andpresent Bombers players. The fallout may also spell the end for Hird asan AFL senior coach.
Click here for full coverage of the Essendon supplements saga
If Justice Middleton rules in favour of the club and its coach, ASADAwill potentially need to decide whether to conduct a freshinvestigation. Hird may also sue ASADA and possibly the AFL.
AFL CEO Gillon McLachlan said the League has "contemplated" the various scenarios.
"Quite obviously we've contemplated each of them," he told ABC radio on Friday morning.
"As I've said repeatedly, we're not party to it, so it's Essendon and ASADA. So ours is more of a communications planning rather than actually anything more substantive than that."
A three-day trial in August heard sensational evidence from Hird and theformer chief executive of ASADA Aurora Andruska about the handling ofthe supplements saga.
After the hearing phase of the trial, Bomberschairman Paul Little called on the Federal Government to step in as a'circuit-breaker' and make the matter 'go away' if the judgement went the club's way.
The judgement will be delivered just hours before Friday night'spreliminary final between the Sydney Swans and North Melbourne at ANZStadium.
Essendon's season ended with an elimination final loss to North Melbourne.