INAUGURAL Giants Sam Reid and Matt Buntine have been delisted among four list changes for the club.
Academy graduate Nick Shipley and Tom Hutchesson were also not offered contracts for 2022.
It brings an end to a remarkable career for Reid, who retired at the end of 2013 before returning two years later to play another 84 games across six seasons.
The 31-year-old, who began his career at the Western Bulldogs in 2008, played every game in the Giants' 2019 season where they reached the Grand Final.
Buntine also arrived at the Giants in the inaugural season of 2012, having been selected at pick No.5 in the 2011 NAB AFL Draft.
He played 67 games over 10 seasons at the club and held positions in the club’s emerging leaders’ group across his time path the club.
WHO'S CALLED IT QUITS 2021's retirements and delistings
"As foundation players who have been at the Giants since day one, Sam and Matt have contributed enormously to our club, both on and off the field, over the past decade," Giants general manager of football Jason McCartney said.
"We thank them for their roles in building the Giants during our formative years, they will always have an indelible place in the club’s history.
"We wish Sam, Elissa and Elijah, along with Matt and Bessie, all the best for the future."
Shipley, 22, was the club’s first-ever Academy graduate from Western Sydney and managed six senior games, including four this season, since his debut in 2018.
Hutchesson joined the club as a mature-age draftee at the age of 24 in 2019 and played one game in his two seasons at the club.